What is the difference between Nucleofill and Rejuran?

Both are polynucleotide skin boosters but Rejuran is Korean (PN at lower concentration ~2%) while Nucleofill is Italian (Promoitalia, 2.5% PN concentration). Nucleofill comes in 4 variants (Medium, Strong, Soft Plus, Medium Plus) for customized intensity. Rejuran has 3 variants (Healer, I, S/HB).

How is Nucleofill different from HA fillers like Profhilo?

Profhilo uses hyaluronic acid for hydration and bio-remodelling. Nucleofill uses PDRN (polynucleotide) which works through a different mechanism — activating purinergic receptors on cell surfaces to trigger genuine tissue repair, collagen synthesis, and DNA-level cell regeneration. Many patients combine the two for layered effect.

How long does Nucleofill last?

Nucleofill effects build progressively over 1–3 months and last 9–12 months. Initial hydration appears in 1–2 hours, metabolic activation peaks at 48 hours, the polynucleotide degrades over 7–10 days, but the regenerative effects on collagen and tissue continue for many months after. Maintenance every 9–12 months is typical.

Is Nucleofill suitable for under-eye treatment?

Yes. Nucleofill Soft Plus or Medium Plus are designed for delicate under-eye skin — improving dark circles, hollow appearance, and skin texture. Unlike HA fillers under the eye (which can pool or create Tyndall effect), Nucleofill regenerates the skin itself rather than adding volume.

Are there side effects?

Mild redness and swelling for 1–2 days are normal. Nucleofill is well-tolerated as PDRN is structurally similar to human DNA. Rare side effects include bruising at injection sites. Not for patients with active infections or pregnant/breastfeeding women. VERZO CLINIC uses only authentic Promoitalia product with traceable lot numbers.

How do I book a Nucleofill consultation at VERZO CLINIC?

Consultation can be arranged via LINE @verzo, WhatsApp +66-95-326-6644, or walk-in. Clinic is 100m from BTS Ekkamai Exit 1 at 988-990-992 Sukhumvit Road, Bangkok. Open daily 10:00-19:00.

Is Nucleofill safe during pregnancy or breastfeeding?

Nucleofill is not recommended during pregnancy or breastfeeding due to insufficient safety data in these populations. VERZO CLINIC follows international consensus and asks all patients to disclose pregnancy status during consultation. Treatment can resume after weaning. If you discover pregnancy after treatment, the risk is generally considered low but inform your obstetrician.

What payment options are available at VERZO CLINIC for Nucleofill?

VERZO CLINIC accepts cash, credit cards (Visa, Mastercard, JCB, AMEX), bank transfer, and major Thai e-wallets (PromptPay, TrueMoney). We also accept international cards for medical-tourism patients with no foreign transaction fees on our side. Payment is confirmed at consultation.

How does VERZO CLINIC ensure Nucleofill authenticity?

VERZO CLINIC sources Nucleofill only through authorized Thailand distributors with verifiable lot numbers and supply chain. Original packaging is shown to patients on request, and lot numbers are recorded in your medical chart for traceability. We do NOT use grey-market or parallel-import products. Authenticity is fundamental to safety in aesthetic medicine.

What languages does VERZO CLINIC offer for Nucleofill consultations?

VERZO CLINIC offers consultations in Thai (native), English (fluent), Japanese, Mandarin Chinese, Korean, Spanish, Portuguese, French, Bahasa Melayu, and basic Arabic. For international patients we recommend booking ahead via LINE @verzo or WhatsApp +66-95-326-6644 to ensure language-matched doctor availability. Translation support is available on request for less common languages.

How often should I schedule Nucleofill maintenance treatments?

For sustained results, Nucleofill maintenance is typically recommended every 6–12 months. Individual cadence varies by metabolism, lifestyle factors (sun exposure, smoking, exercise), and original treatment intensity. Your VERZO CLINIC doctor will create a personalized maintenance schedule during your follow-up review.

Nucleofill Polynucleotide Gel Bangkok | VERZO CLINIC Ekkamai

Nucleofill by Promoitalia (Italy) is a premium 2.5% polynucleotide gel derived from wild salmon sperm DNA. It works through PDRN receptor activation — a lock-and-key mechanism where polynucleotide molecules activate purinergic receptors on cell surfaces, triggering deep tissue repair and collagen synthesis. Available in 4 variants (Medium, Strong, Soft Plus, Medium Plus) for customized treatment. Pharmacokinetics: hydration 1-2 hours, metabolic activation 48 hours, degradation 7-10 days. Italian manufacturing, registered with the Thai FDA (อย.). Available at VERZO CLINIC Bangkok near BTS Ekkamai. Prices may vary. Consultation required for personalized treatment plan.

Nucleofill Key Facts — 2026

2.5% PDRN concentration
Manufacturer: Promoitalia (Italy) — premium European GMP
4 variants: Medium, Strong, Soft Plus, Medium Plus — customized to treatment area
Pharmacokinetics: hydration 1-2h → metabolic activation 48h → degradation 7-10 days → elimination 15 days
Derived from wild salmon sperm DNA — high biocompatibility with human cells
Results last 9-12 months with progressive improvement over 1-3 months
Nucleofill polynucleotide at VERZO CLINIC: session count and volume are planned by the doctor at consultation

About Nucleofill Polynucleotide Gel

Manufacturer: Promoitalia (Italy). Certifications: Registered with the Thai FDA (อย.), Italian GMP manufacturing.

How it works: Nucleofill contains PDRN (polydeoxyribonucleotide) derived from wild salmon sperm DNA. PDRN activates cell receptors through a "lock and key" mechanism — the polynucleotide molecules fit precisely into purinergic receptors on cell surfaces, triggering cellular repair, collagen synthesis, and tissue regeneration. Pharmacokinetics: hydration effect in 1-2 hours, metabolic activation at 48 hours, degradation at 7-10 days, complete elimination at 15 days.

Key technology: PDRN (polydeoxyribonucleotide) from wild salmon sperm at 2.5% concentration — activates purinergic cell receptors like a lock-and-key mechanism

Treatment Areas

Full face
Under-eye area
Neck
Hands
Body areas with skin laxity

Who Is Nucleofill Suitable For?

Deep wrinkles and sagging skin needing intensive repair
Those seeking long-lasting skin-renewal results (9-12 months)
Under-eye dark circles and hollows
UV-damaged skin requiring deep regeneration
Patients preferring premium European products with clinical evidence
Skin that has lost elasticity and bounce

Aftercare for Nucleofill

Mild swelling and redness for 1-2 days is normal
Avoid heat exposure for 24-48 hours
Stay hydrated to support tissue regeneration
Results build progressively over 1-3 months
Consider maintenance session at 9-12 months

Nucleofill Pricing at VERZO CLINIC Bangkok

Nucleofill polynucleotide at VERZO CLINIC: the doctor plans the number of sessions at consultation. Contact us for a current quote before booking.

Location: VERZO CLINIC, 988-990-992 Sukhumvit Road, near BTS Ekkamai, Bangkok. Open daily 10:00-19:00.

Contact: LINE @verzo | WhatsApp +66-95-326-6644